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In conclusion, the classification of calcium carbonate factories is a reflection of the diverse applications and requirements of this compound. Each type, whether natural or synthetic, large or small-scale, or specialized in a specific product, contributes significantly to various industries, demonstrating the versatility and importance of calcium carbonate in our daily lives. As technology advances and sustainability becomes more crucial, it is expected that these classifications will continue to evolve, adapting to the changing needs of the market and environment.

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Additionally, the committee noted that the available data did not provide convincing evidence of genotoxicity for titanium dioxide as a food additive, but recognized the limitations in current methodologies with respect to the testing of poorly soluble particulate materials. Although there were uncertainties in the genotoxicity data, the experts took into account the fact that the additive was not carcinogenic in adequately conducted two-year studies in mice and rats at doses of up to 7,500 mg/kg BW per day for mice, and 2,500 mg/kg BW per day for rats, the highest doses tested. There was also no evidence of reproductive or developmental toxicity in studies in rats at doses up to 1,000 mg/kg BW per day, the highest doses tested.  

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